INSIDER: alignment-free detection of foreign DNA sequences
نویسندگان
چکیده
منابع مشابه
gpALIGNER: A Fast Algorithm for Global Pairwise Alignment of DNA Sequences
Bioinformatics, through the sequencing of the full genomes for many species, is increasingly relying on efficient global alignment tools exhibiting both high sensitivity and specificity. Many computational algorithms have been applied for solving the sequence alignment problem. Dynamic programming, statistical methods, approximation and heuristic algorithms are the most common methods appli...
متن کاملAn alignment-free method to find and visualise rearrangements between pairs of DNA sequences
Species evolution is indirectly registered in their genomic structure. The emergence and advances in sequencing technology provided a way to access genome information, namely to identify and study evolutionary macro-events, as well as chromosome alterations for clinical purposes. This paper describes a completely alignment-free computational method, based on a blind unsupervised approach, to de...
متن کاملGenomic Signal Processing Methods for Computation of Alignment-Free Distances from DNA Sequences
Genomic signal processing (GSP) refers to the use of digital signal processing (DSP) tools for analyzing genomic data such as DNA sequences. A possible application of GSP that has not been fully explored is the computation of the distance between a pair of sequences. In this work we present GAFD, a novel GSP alignment-free distance computation method. We introduce a DNA sequence-to-signal mappi...
متن کاملgpaligner: a fast algorithm for global pairwise alignment of dna sequences
bioinformatics, through the sequencing of the full genomes for many species, is increasingly relying on efficient global alignment tools exhibiting both high sensitivity and specificity. many computational algorithms have been applied for solving the sequence alignment problem. dynamic programming, statistical methods, approximation and heuristic algorithms are the most common methods applied t...
متن کاملMethylation of foreign DNA sequences in eukaryotic cells.
The herpesvirus thymidine kinase gene has been used to introduce foreign DNA sequences into mouse L cells by DNA-mediated gene transfer. These inserted genes were then assayed for methylation at the specific sequence C-C-G-G by using the restriction enzyme isoschizomers Hpa II and Msp I. Despite the fact that 70% of the cellular C-C-G-G sites are methylated, herpesvirus sequences, plasmid DNA, ...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2021
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2021.06.045